Are COVID-19 Vaccines Going To Cause Infertility?

Severe acute respiratory syndrome coronavirus 2 infection during the first trimester of pregnancy does not seem to predispose to early pregnancy loss; its cumulative incidence did not differ between women with spontaneous abortion and women with ongoing pregnancy.

The COVID-19 pandemic environment does not seem to affect early first-trimester miscarriage rates in asymptomatic patients.

In this cohort study of 252 SARS-CoV-2–positive and 3122 negative pregnant women tested in outpatient and inpatient settings at a large county medical center, adverse pregnancy outcomes were similar, and neonatal infection occurred in 3% of infants, predominantly among infants born to asymptomatic or mildly symptomatic women. Placental abnormalities were not associated with disease severity, and the rate of hospitalization was similar to rates among nonpregnant women.

usually requires extensive sequence homology, e.g. >35% identity in >50–80 aa peptidic sequences (conformation!) and a linkage of the cross-reacting B-cell epitope to a dominant T helper epitope (foreign). It is facilitated by a strong concomitant activation of innate immunity (danger signal!) [62].

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